Effect of modified neoadjuvant chemotherapy on levels of E6 oncoprotein in HPV-infected cervical tumor tissue

. Background. Human papillomavirus (HPV) has been established to be the etiological factor of cervical cancer (CC). HPV infection and CC progression involve direct participation E6 oncoprotein. Aim. An analysis oncoprotein levels in tissues tumor its perifocal area HPV-associated squamous cell as an objective indicator effect treatment depending on preoperative chemotherapy. Material methods. The study included clinical laboratory data 237 patients with high-risk cervix. were divided into 4 groups: two main groups (CC T2а2–2bN0–1M0) control groups. Patients group 1 (n=84) received standard neoadjuvant chemotherapy (NACT), 2 (n=93) — modified NACT prior plasmapheresis session a parallel course nonspecific immunotherapy Allokin-alpha. Control (n=40) T1b2–2a1N0–1M0, surgical treatment; (n=20) HPV-positive without CC. Levels measured samples tissues. Results. lowest registered After NACT, remained 4.6 times higher than intact tissues, even so, these demonstrated minimal compared other patients. was significantly lower (by 3.3 times) 8 1. 1.9 corresponding 2.2 Conclusions. Inclusion inducers endogenous interferonogenesis for can considered pathogenetically justified, since it affects key unit carcinogenesis.